CN EN

Structure and function characterization & New formulation development platform

Structural characterization and
development of novel formulations
  • Denaturing MS molecular weight analysis
  • Native MS molecular weight analysis
  • Amino acid complete sequence analysis
  • Post-translational modification analysis
  • Extinction coefficient analysis
  • N-glycosylation/O-glycosylation site identification
  • N-glycosylation/O-glycosylation composition analysis
  • Sialic acid content analysis
  • CEX-MS analysis
  • Sequence variant analysisAcid-base peak identification analysis
  • Polymeric fragment identification analysis
  • BsAb mismatch analysis
  • HCP qualitative analysis
  • Qualitative and quantitative analysis of high-risk HCPs
  • HCP coverage rate analysis
  • Analysis of Tween degradation products
  • Epitope analysis
  • Advanced Structure Analysis
  • High concentration preformulation development
  • PFS preformulation development
  • Co-prescription preformulation development
Research methods
  • RP-MS/SEC-MSNative SEC-MS
  • RP-MS/MS
  • RP-MS/MS
  • RP-HPLC-FLD
  • RP-MS/MS (conventional or H2O18 method)
  • RP-MS/MS
  • RP-HPLC-FLD
  • CEX-MS
  • RP-MS/MS
  • CEX-HPLC/ RP-MS, MS/MS
  • SEC-HPLC/ RP-MS, MS/MS
  • (iCIEF or HIC) /CE/ RP-MS
  • RP-MS/MS (DDA)
  • RP-MS/MS (DDA&MRM)
  • 2D SDS-PAGE/Western Blot
  • RP-HPLC-CAD/QDA
  • Epitope competition, HDX-MS, Al prediction
  • HDX-MS
  • Buffer/protectant/viscosifier screening
  • Buffer/protectant/package screening
  • Buffer/protectant etc screening
Comprehensive characterization study
Evaluation and development of high concentration preparations
Multidimensional epitope analysis