CN EN

Pharmacological efficacy and pharmacokinetic evaluationplatform

Pharmacological efficacy and pharmacokinetic evaluation
  • Antigen-specific binding activity
  • Antigen cross binding activity
    (human, mouse, monkey)
  • Epitope analysis
  • Receptor occupancy rate
  • FcγR/FcRn/C1q binding activity
  • Tumor cell surface antigen detection
  • Biological activity (proliferation inhibition)
  • Biological activity (cell killing)
  • Biological activity (reporter gene method)
  • Cytokine release
  • Endocytosis experiment
  • ADCC/CDC/ADCP
  • Bystander effect
  • Cell Cycle
  • Plasma stability (human, mouse, monkey)
  • CDX efficacy experiment
  • PDX efficacy experiments
  • mAb/BsAb blood concentration detection
  • Exfoliating small molecule (free drug)
    blood drug concentration detection
  • ADC blood concentration detection
  • Total antibody blood concentration detection
Analytical
methods
  • BLVELISA
  • BLVELISA
  • BLU/HIX
  • FACS
  • BLVELISA
  • FACS
  • Cell-based assay
  • Cell-based assay
  • Cell-based assay
  • ELISA
  • Cell-based assay
  • Cell-based assay
  • Cell-based assay
  • Cell-based assay
  • ELISA & MS
  • Animal experiments
  • Animal experiments
  • ELISA
  • LC-MS/MS
  • ELISA
  • ELISA
Binding (ELISA)
Binding (FACS)
Antigen Affinity (BLI)
CD16a(v176) affinity (BLI)
FcRn affinity (BLI)
Dual Target Binding (BLI)
ADCC
CDC
ADCP
Endocytosis (pHrodo)
Bystander Effect (RTCA)
Cell cycle arrest (FACS)