| Serial number | Linker-payload Structural formula | Coupling made | Suggested DAR values |
|---|---|---|---|
| 1 |
MC-VC-PAB-MMAE
|
Sulfhydryl chemical coupling | 2-4 |
| 2 |
MC-VC-PAB-Eribulin
|
Sulfhydryl chemical coupling | 2-4 |
| 3 |
Mal-PEG2-VC-PAB-Eribulin
|
Sulfhydryl chemical coupling | 2-4 |
| 4 |
MC-GGFG-Dxd
|
Sulfhydryl chemical coupling | 6-8 |
| 5 |
Mal-PEG8-VA-PAB-Exatecan
|
Sulfhydryl chemical coupling | 4-8 |
| 6 |
Mal-Gly-PAB-Exatecan-D-glucuronic acid
|
Sulfhydryl chemical coupling | 4-8 |
| 7 |
BiM-GLPY-Exatecan
|
Sulfhydryl sulfur bridge coupling | 4-8 |
| 8 |
BrAcAm-VA-A-1743332
|
Mercaptobromine coupling | 4-8 |
| 9 |
GSI-P001, TOPi-based, highly hydrophilic
--
|
Sulfhydryl chemical coupling | 4-8 |
| 10 |
GSI-P002, TOPi-based, highly hydrophilic
--
|
Sulfhydryl sulfur bridge coupling | 4-8 |
| 11 |
GSI-P003，GSI-P004
--
|
-- | 4-8 |
