MeCHOta® Cell
Line Development

JSBio is your dependable cell culture technology partner. Boasting extensive experience and a professional team, we can offer services in cell culture process development, such as optimization of culture conditions (inoculum density, agitation rate, aeration, temperature, pH, etc.), and process scale-up, to help you achieve higher product yields and enhanced quality. At the same time, we will fully support your IND and BLA submissions.

Recombinant protein upstream production process

  • Fed-batch process development platform (CHO, HEK-293)
  • Perfusion culture process development platform (CHO, HEK-293)

Viral vaccine upstream production process

  • Serum adherent culture process platform
  • Low serum adherent culture process platform (Vero, MRC-5/2BS, Marc-145)
  • Serum-free adherent culture process platform (Vero)
  • Low serum suspension culture process platform (BHK-21, F81)
  • Serum-free suspension culture process platform (BHK-21, 293FT/T, LMH,MDBK, MDCK, PK-15, PMA, Sf9/H5, ST)
Cell Culture Process
Development Flow
  • Adequate project information communication, clarify customer demands
    1
  • Signing material transfer agreements (MTAs) and technical service contracts for material and technology transfer.
    2
  • Medium development and determination of the optimal medium
    3
  • Shake flask cell culture process development
    4
  • Reactor cell culture process development
    5
  • Result analysis, process optimization and validation
    6
  • Process scale-up (in customer's lab)
    7
  • Technology transfer and validation, determination of processes
    8
  • Documentation support related to IND/BLA declarations
    9